重大的

Important changes are already in the pipeline.

变革已在酝酿之中。

This was the greatest event in the annals of European integration.

这是欧洲统一史上最事件。

Your vote can be of real significance in the outcome of the election.

你们投票对于选举最后结果可能有意义。

They were understood to have reviewed all major foreign policy issues.

据了解, 他们讨论了所有外交政策问题。

Through similar and supplementary action , polygenes can have important effects on total variability.

通过相同和添加作用，多基因可以对总变异起影响。

Penicillin was acclaimed as the most important discovery during the 1940's.

青霉曾被公认是二十世纪四十年代最发现。

The registry holds records of all major operations.

登记处有所有手术记录。

The present aspect of society is portentous of great change.

现在示着变革发生。

It is a discovery that made medical history.

这是载入医学史册发现。

It's the big moment in my life.

这是我一生中时刻。

She knew wherein her gross defects lay.

她知道自己缺点在哪里。

This is a significant contribution to knowledge.

这是对知识贡献。

How should we most effectively use science to reduce or eradiate this huge burden of diesase?

我们应该怎样最有效利用科学，来减少或者消灭这一疾病负担？

This is a book that displays the considerable scholarship of its author.

这是一本表现作者学术成就书。

The Government's decision is a real kick in the teeth for the unions.

政府决定是对工打击。

Blindness is a great handicap.

失明是一种残疾。

That's a great decision indeed.

那确是一项决定。

Her wedding was the event of the year.

她婚礼是那一年事件。

With the establishment of major new markets, the economy is thriving.

随着新市场建立，经济越来越兴旺。

The invention of the wheel was a milestone in the history of the world.

发明轮子是世界历史上事件。