重大

The brigadier was cashiered for his big mistake.

旅长因犯错误而被革职。

It is a discovery that made medical history.

这是载入医学史册发现。

Important changes are already in the pipeline.

变革已在酝酿之中。

Researchers believe that they are onto something big.

研究人员认为他们将有发现。

The registry holds records of all major operations.

登记处有所有手术记录。

It's the big moment in my life.

这是我一生中时刻。

This was the greatest event in the annals of European integration.

这是欧洲统一史上最件。

She knew wherein her gross defects lay.

道自己缺点在哪里。

This is a significant contribution to knowledge.

这是对识贡献。

He incurred a heavy loss through you.

他因为你而遭受损失。

This is a book that displays the considerable scholarship of its author.

这是一本表现作者学术成就书。

The Government's decision is a real kick in the teeth for the unions.

政府决定是对工会打击。

The present aspect of society is portentous of great change.

现在社会预示着变革发生。

His accession to the important post was a big event.

他就任这一要职务是一个件。

Her wedding was the event of the year.

婚礼是那一年件。

With the establishment of major new markets, the economy is thriving.

随着新市场建立，经济越来越兴旺。

Doctors are making great inroads in the fight against cancer.

在抗癌战斗中医生正取得进展。

The invention of the wheel was a milestone in the history of the world.

发明轮子是世界历史上件。

She views every minor setback as a disaster.

把每个较小挫折都看成灾难。

Their boycott of the talks constitutes a serious impediment to peace negotiations.

他们联合抵制会谈行为成了和谈障碍。