She knows physiology from beginning to end.

生理学这门学科了如指。

She knows the layout of the back streets like the back of her hand.

那些偏僻的街道了如指。

Tony is very hot on local history.

托尼当地历史了如指。

She knows every nook and cranny of the city, so she’s the perfect guide.

这个城市了如指，让做向道是再好不过了。