Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

摘要目的观察罗通定与阈下剂量哌用后对哌镇痛作用的影响。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

结论罗通定与阈下剂量派用可以增强镇痛效果，从而减少派的用量，低其药物依赖的发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取白花败酱草水提取液分别单独、配伍使用阈上或阈下剂量的戊巴比妥钠注入内,观察的自发活动和睡眠时间,并将结果与对照组进行比较、分析。

Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

摘要目的观察定与下剂量哌替啶合后对哌替啶镇痛作的影响。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

结定与下剂量派替啶合可以增强镇痛效果，从而减少派替啶的量，低其药物依赖的发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取白花败酱草水提取液分别单独、配伍上或下剂量的戊巴比妥钠注入小鼠体内,观察小鼠的自发活动和睡眠时间,并将结果与对照组进行比较、分析。

Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

摘要目的观察罗通定与下剂量哌替啶合用后对哌替啶镇痛作用的影。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

罗通定与下剂量派替啶合用可以增强镇痛效果，从而减少派替啶的用量，低其药物依赖的发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取白花败酱草水提取液分别单独、配伍使用下剂量的戊巴比妥钠注入小鼠体内,观察小鼠的自发活动和睡眠时间,并将果与对照组进行比较、分析。

Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

的观察罗通定与阈下剂量哌替啶合用后对哌替啶镇痛作用的影响。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

结论罗通定与阈下剂量派替啶合用可以增强镇痛效果，从而减少派替啶的用量，低其药物依赖的发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取白花败酱草水提取液分别单独、配伍使用阈上或阈下剂量的戊巴比妥钠注入小鼠体内,观察小鼠的自发活动和睡,并将结果与对照组进行比较、分析。

Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

摘要目的观察罗通定与阈下哌替啶合用后对哌替啶镇痛作用的影响。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

结论罗通定与阈下替啶合用可以增强镇痛效果，从而减少替啶的用，低其药物依赖的发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取白花败酱草水提取单独、配伍使用阈上或阈下的戊巴比妥钠注入小鼠体内,观察小鼠的自发活动和睡眠时间,并将结果与对照组进行比较、析。

Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

的观察罗通定与阈下剂量哌替啶合用后对哌替啶镇痛作用的影响。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

结论罗通定与阈下剂量派替啶合用可以增强镇痛效果，从而减少派替啶的用量，低其药物依赖的发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取白花败酱草水提取液分别单独、配伍使用阈上或阈下剂量的戊巴比妥钠注入小鼠体内,观察小鼠的自发活动和睡,并将结果与对照组进行比较、分析。

Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

摘要目的观察罗通定与阈下剂量哌替啶合用后对哌替啶镇痛作用的影响。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

结论罗通定与阈下剂量派替啶合用可以增强镇痛效果，从而减少派替啶的用量，低其药物依赖的发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取白花败酱草水提取液分别单独、配伍使用阈上或阈下剂量的戊巴妥钠注入小鼠体内,观察小鼠的自发活动和睡眠时间,并将结果与对照组较、分析。

Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

摘要目的观察罗通定与阈下剂量哌替啶合用后对哌替啶镇痛作用的影响。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

结论罗通定与阈下剂量派替啶合用可镇痛效果，从而减少派替啶的用量，低其药物依赖的发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取酱草水提取液分别单独、配伍使用阈上或阈下剂量的戊巴比妥钠注入小鼠体内,观察小鼠的自发活动和睡眠时间,并将结果与对照组进行比较、分析。

Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

摘要目观察罗通定与阈下哌替啶合后对哌替啶镇影响。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

结论罗通定与阈下派替啶合可以增强镇效果，从而减少派替啶，低其药物依赖发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取白花败酱草水提取液分别单独、配伍使阈上或阈下戊巴比妥钠注入小鼠体内,观察小鼠自发活动和睡眠时间,并将结果与对照组进行比较、分析。