The brigadier was cashiered for his big mistake.

旅长因犯重大错误而被革职。

It is a discovery that made medical history.

这是载入医学史册的重大发现。

Important changes are already in the pipeline.

重大的变革已在酝酿之。

Researchers believe that they are onto something big.

研究人员认为他们将有重大发现。

The registry holds records of all major operations.

登记处有所有重大手术的记录。

It's the big moment in my life.

这是我的重大时刻。

This was the greatest event in the annals of European integration.

这是欧统史上最重大的件。

She knew wherein her gross defects lay.

知道自己的重大缺点在哪里。

This is a significant contribution to knowledge.

这是对知识的重大贡献。

He incurred a heavy loss through you.

他因为你而遭受重大损失。

This is a book that displays the considerable scholarship of its author.

这是本表现作者重大学术成就的书。

The Government's decision is a real kick in the teeth for the unions.

政府的决定是对工会的重大打击。

The present aspect of society is portentous of great change.

现在的社会预示着重大变革的发。

His accession to the important post was a big event.

他就任这重要职务是个重大件。

Her wedding was the event of the year.

的婚礼是那年的重大件。

With the establishment of major new markets, the economy is thriving.

随着重大新市场的建立，经济越来越兴旺。

Doctors are making great inroads in the fight against cancer.

在抗癌的战斗医正取得重大进展。

The invention of the wheel was a milestone in the history of the world.

发明轮子是世界历史上的重大件。

She views every minor setback as a disaster.

把每个较小的挫折都看成重大灾难。

Their boycott of the talks constitutes a serious impediment to peace negotiations.

他们联合抵制会谈的行为成了和谈的重大障碍。