Histopathologic examination showed hyperkeratosis of epidermis, increased thickness of the granular layer and dilation of subpapillary vessels filled with red blood cells.
Such involvement of dermal lymphatics gives the grossly thickened, erythematous, and rough skin surface with the appearance of an orange peel ("peau dorange" for you francophiles).
The change of the control group's histomorphology was clear: the incrassation of synovial lining cells, the infiltration of Inflammatory cells and the erosion of nephelium of blood vessels on hones.
Other explanations include things like the hypertrophy range increasing muscle pump, improving mind-muscle connection, increasing time under tension, and among many others.
It's followed by the proliferative phase, during which the rising levels of ovarian estrogen make the functional layer of the endometrium thicken and sprout endometrial glands.
Over time, as a reaction to the immune deposits, GBM matrix is deposited in between the immune complexes, which makes the GBM appear thickened on histology.