Objective To investigate the synergistic analgesic action of rotundine combined with subthreshold dose of dolantin.

摘要目的观察罗通定与阈下剂啶合用后对啶镇痛作用的影响。

Conclusion The combined administration of dolantin and rotundine has significant synergistic action of analgesia, with reduced dose of dolantin and decreased incidence of addiction.

结论罗通定与阈下剂派啶合用可以强镇痛效果，从而减少派啶的用，降低其药物依赖的发生概率。

Methods The aqueous extract of all grass of Patrina villosa Juss was injected peritoneally to mice or that accompanied with suprathreshold or subthreshold dose of pentobarbital solution.

方法取白花水提取液分别单独、配伍使用阈上或阈下剂的戊巴比妥钠注入小鼠体内,观察小鼠的自发活动和睡眠时间,并将结果与对照组进行比较、分析。