In fact, the mesangium is continuous with the smooth muscles of the afferent and efferent arterioles, and fills in the space between the loops of blood vessels, hence the name.
In arterioles, a process called hyaline arteriolosclerosis is where the walls of arterioles where they develop hyaline deposits, which are the deposits of proteins, and these make them hard and inflexible.
And if the weak spot ruptures in a smaller arteriole blood vessel — say, one that leads to an organ like a kidney or eye, it can lead to organ damage or failure.
Sexual arousal triggers the parasympathetic reflex that causes arterioles in the external genitalia to dilate and fill with blood, which is actually one of the only times the parasympathetic system controls any arteriole action.
So, in the case of hypovolemia and hypotension, the macula densa cells sense the low sodium and chloride levels and send a signal over to the juxtaglomerular cells which are located in the wall of the afferent arteriole.