The disorder is known as spino-cerebellar ataxia type 1, or SCA-1.

这种疾病被“髓小脑型济1型(SCA-1)”。

He has fever, sweats, tingling in his lips, fingers and toes, mood swings and lack of coordination.

他有发热，出汗，舌、手指、脚趾麻木，感情绪波动和济。

Alright as a quick recap, spinocerebellar ataxia is a group of progressive neurodegenerative diseases of genetic origin.

得！快速回顾一下～髓小脑性济是一组遗传性进行性经退行性疾病。

If this happens, it causes Angelman syndrome, which results in severe intellectual diability, seizures, and ataxia.

如果此基因突变，则导致安格尔曼综合征，患者出现严重的智力残疾、癫痫和济。

Motor symptoms can include muscle weakness, muscle spasms, tremors, and ataxia, which is a loss of balance and coordination.

运动症状包括肌无力、肌痉挛、震颤和济（去平衡和协运动）。

In fact, many different gene mutations have been identified each of which is known to cause different types of spinocerebellar ataxia.

实际上，目前已经鉴定出不同的基因突变；每种突变都会导致不同类型的髓小脑性济。

These mutations result in degenerative changes in the cerebellum and often in the spinal cord which causes progressive problems with coordination and balance known as ataxia.

这些突变导致小脑和髓的退行性改变，这会导致进行性运动协障碍、平衡障碍等，济。

They typically die around 20 years later, of causes related to breathing or swallowing problems. The disorder is known as spino-cerebellar ataxia type 1, or SCA-1.

他们通常会在大约 20 年后死于与呼吸或吞咽问题有关的原因。这种疾病被 1 型髓小脑性济或 SCA-1。