不可救药

He has an incurable and widespread nepotism.

有不可救药，到处蔓延裙带主义。

They are trying to cure him of his drug addiction but he is beyond hope.

治愈毒瘾, 但是已经不可救药。

My children are hopelessly addicted to television.

我几个孩子都成电视迷,简直是不可救药。