Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素为起始原,解、乙酰化、环碳酸酯化、氧化、脱碳酸酯化、酰化、环氨基甲酸酯化和环合等反应合成目标化合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。

Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素为起始原料,经、乙、环碳酸、氧、脱碳酸、、环氨基甲酸和环合等反应合成目标合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙和去乙由一对功能相互拮抗的蛋白酶——组蛋白乙基转移酶和组蛋白去乙酶负责。

Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素为起始原料,经水解、乙酰、环碳酸、、脱碳酸、酰、环氨基甲酸和环合等反应合成目标合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙酰和去乙酰由一对功能相互拮抗的蛋白——组蛋白乙酰基转移和组蛋白去乙酰负责。

Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素原料,经水解、乙酰化、环碳酸酯化、氧化、脱碳酸酯化、酰化、环氨基甲酸酯化和环合等反应合成目标化合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。

Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素为起始原料,经水解、乙酰化、碳酸酯化、氧化、脱碳酸酯化、酰化、氨基甲酸酯化和反应成目标化物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。

Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素为起始原料,经水解、乙酰、环碳酸酯、氧、脱碳酸酯、酰、环氨基甲酸酯环合等反应合成目标合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙酰乙酰由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶组蛋白乙酰酶负责。

Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素为起始原料,经水解、乙酰、环碳酸酯、氧、脱碳酸酯、酰、环氨基甲酸酯环合等反应合成目标合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙酰乙酰由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶组蛋白乙酰酶负责。

Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素为起始原料,经水解、乙酰化、碳酸酯化、氧化、脱碳酸酯化、酰化、甲酸酯化和合等反应合成目标化合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组乙酰化和去乙酰化由一对功能相互拮抗的酶——组乙酰转移酶和组去乙酰化酶负责。

Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以拉霉素为起始原料,经水解、乙酰、环碳、氧、脱碳、酰、环氨基甲环合等反应合成目标合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙酰去乙酰由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶组蛋白去乙酰酶负责。