Protein C or S deficiency is commonly asymptomatic, but symptoms arise when a venous thromboembolism develops.

蛋白C和S缺乏症患者一般无临床症状，当栓栓塞时可出现症状。

Symptoms of venous thromboembolism include pain similar to a muscle cramp, and swelling in the affected leg.

栓栓塞的症状包括类似肌肉痉挛的疼痛以及患侧腿部肿胀。

A deep vein thrombosis can also send off a thromboembolism to the lungs which can cause a sudden pulmonary embolism which can be fatal.

深栓也可能脱落栓栓子；其到肺部可导致致命的肺栓塞。

Most people present with venous thromboembolism, where a blood clot of the leg veins or lung circulation is most common.

大部分患者会出现栓栓塞，最常见的是在腿部及肺循环中栓。

Initial treatment of venous thromboembolisms is the same as it would be for patients with normal protein C and protein S levels.

对栓栓塞的初步治疗，与对拥有正常水平蛋白C和S的患者治疗是一样的。

Protein C or protein S deficiency is also sometimes suspected when a venous thromboembolism develops in an unusual site like the portal, mesenteric, or cerebral veins.

当栓栓塞出现在不常见的部位时，也要怀疑蛋白C或蛋白S缺乏症，比如门、肠系膜或脑部。

Protein C or S deficiency is suspected in people with a strong family history of coagulation disorders, especially those who suffer from recurrent venous thromboembolisms and experience their first thrombotic event before age fifty.

有明显凝功能障碍家族史的患者可怀疑蛋白C或蛋白S缺乏症，尤其是反复出现栓栓塞，且于50岁之前发生第一次栓塞的患者。

Another UK study published last year found incidences of and deaths from thromboembolism doubled in the first six months of the pandemic compared to rates seen in the years prior.

去年发表的另一项英国研究发现，与前几年相比，在大流行的前六个月，栓栓塞的发病率和死亡率翻了一番。

A more serious presentation is neonatal purpura fulminans, which is when a newborn with protein C or S deficiency suffers massive arterial and venous thromboembolisms with hemorrhagic skin necrosis.

更严重的并发症是新生儿暴发性紫癜，即患有蛋白C和S缺乏症的新生儿出现大量动栓栓塞及出性皮肤坏死。