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Furthermore, PTP1B deletion significantly reduced gene expression of 3 1-adrenergic receptor subtypes, consistent with blunted constriction to phenylephrine.

此外PTP1B缺乏明显减少31-肾上腺受体亚型基因表达,与对福林收缩反应迟

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HPLC method for determination of phenylephrine hydrochloride, paracetamol, caffeine anhydrous,salicylamide and brompheniramine maleate in Liufenkamin tablets was established.

HPLC法测定柳酚咖敏片中盐酸去氧肾上腺素、对乙酰氨基酚、无水咖啡因、水杨酰胺、马来酸溴苯那敏的含量。

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科学60-科学美国人 2024年2

One of the most popular decongestant ingredients is phenylephrine.

减充血剂最常见成分之一腺素

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科学60-科学美国人 2024年2

Exactly. So, more products started using phenylephrine.

没错。于更多的产品开始使用腺素

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Vox 观点

But I didn't know there was anything wrong with phenylephrine.

但我不知道腺素有什么问题

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Vox 观点

We'll make phenylephrine red because we know it leaves you congested.

我们会让腺素的成像变红,因为我们知道它会让你充血。

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科学60-科学美国人 2024年2

And I always look to see if a decongestant like phenylephrine is in the capsule.

我总看胶囊成分,否含有像腺素这样的减充血剂。

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科学60-科学美国人 2023年10

Overall, though, if oral phenylephrine doesn't work, what should people use instead of it?

总的来说,如果口服腺素不起作用,还有什么更好的替代品吗?

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科学60-科学美国人 2023年10

Yep. Phenylephrine was actually approved in the 1970s, so it had been around a while.

的。苯肾腺素实在20世纪70年代获批的,所以它已经存在了一段时间了。

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科学60-科学美国人 2023年10

Scientists who advise the FDA recently concluded that phenylephrine, a common decongestant in cold medicines, doesn't work.

美国食品和药品管理局(FDA)的顾问科学家最近得出结论:感冒药中常见的减充血剂腺素不起作用。

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Vox 观点

It led to further similarly conclusive studies that phenylephrine was ineffective.

这导致了进一步类似的结论性研究,即腺素无效的。

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Vox 观点

The take-home messages are oral phenylephrine is inaffective as a nasal decongestant but safe.

带回家的信息口服腺素作为减充血剂无效的,但安全。

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Vox 观点

Where nasal congestion went down after taking pseudoephedrine and went like this for a placebo and phenylephrine.

服用伪麻黄碱后鼻塞减轻,服用安慰剂和腺素后鼻塞也减轻

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" 10 milligrams of phenylephrine works no better than a placebo."

“10 毫克腺素的效果并不比安慰剂好。”

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科学60-科学美国人 2023年10

She was on the recent FDA advisory panel earlier this month that made the decision that phenylephrine wasn't effective.

早些时候做出腺素无效决定的FDA顾问小组的专家。

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Vox 观点

By 1976, they'd convened a looser review and a panel recommended Phenylephrine as an oral, nasal decongestant.

到 1976 年,他们召了一个较为宽松的审查小组,并建议将苯肾腺素作为口服鼻塞解充血剂。

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科学60-科学美国人 2023年10

So, the committee voted unanimously that oral phenylephrine is basically useless.

因此,委员会一致认为口服腺素并无缓解鼻塞的功效。

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Vox 观点

And the panelists voting, they seemed a little mystified by how we got to a point where phenylephrine took over.

小组成员投票时,他们似乎有点困惑,为什么我们会走到腺素占据主导地位的地步。

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科学快报-科学美国人2023Science Quickly, from SCIENTIFIC AMERICAN 2023

So, more products started using phenylephrine.

因此,更多的产品开始使用腺素

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科学快报-科学美国人2023Science Quickly, from SCIENTIFIC AMERICAN 2023

Phenylephrine was actually approved in the 1970s, so it had been around a while.

去氧肾腺素实在 20 世纪 70 年代获得批准的,所以它已经存在了一段时间了。

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Vox 观点

Taken from an FDA Zoom meeting these are the votes of FDA panel members on whether phenylephrine is effective.

摘自 FDA Zoom 会议这些 FDA 小组成员对腺素否有效的投票。

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Vox 观点

They have known for decades that phenylephrine might not really work and it's just the process that's gotten in the way.

他们几十年前就知道腺素可能并没有真正起作用,只这个过程阻碍了治疗。

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